NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 25 January 2010 This meta-analysis found aspirin did not statistically significantly reduce the risk of major CV events, CV mortality or all-cause mortality in people with diabetes and no […]
Category Archives: Cardiovascular disease
NPC Archive Item: Apixaban vs. enoxaparin as thromboprophylaxis in knee replacement surgery
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 22 January 2010 In a non-inferiority design, ADVANCE-1 found that results for oral apixaban were similar to s.c. LMWH enoxaparin 30 mg twice daily (not non-inferior) for a primary […]
NPC Archive Item: HEAAL suggests that a higher, unlicensed dose of losartan may have some benefits over the standard dose in heart failure
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 15 January 2010 The HEAAL study compared 50mg and 150mg daily doses of losartan in people with heart failure intolerant of ACE inhibitors. It suggested that the (unlicensed) higher […]
NPC Archive Item: Observational study of hypoglycaemic drugs has limitations
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 15th January 2010 Compared with metformin monotherapy, the fully adjusted analysis in this UK cohort study found no increased risk of heart failure or myocardial infarction with pioglitazone▼ or […]
NPC Archive Item: Cardiovascular outcomes and mortality in patients using clopidogrel with a PPI: more data
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 10 December 2009 A large observational study finds no conclusive evidence for a clinically relevant drug interaction between clopidogrel and PPIs in elderly patients after percutaneous coronary intervention or […]
NPC Archive Item: Darusentan as an add-on in treatment-resistant hypertension
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 9 December 2009, A phase III randomised controlled trial demonstrated that darusentan reduced systolic/diastolic blood pressure by about 10/5mmHg compared with placebo in patients with treatment-resistant hypertension, but was […]
NPC Archive Item: Report considers hospital prescribing of ‘NICE appraised’ and ‘low cost’ medicines.
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 30 November 2009 The NHS Information Centre has issued a report considering expenditure on medicines in hospitals in England in 2008. It includes a table focusing on medicines positively […]
NPC Archive Item: Updated information on adverse effects of statins
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 30 November 2009 The MHRA has published a public assessment report which discusses a review of some of the adverse effects of statins. The review concluded that the following […]
NPC Archive Item: ACE inhibitors, not A2RAs or combination therapy, in ischaemic heart disease
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 12 November 2009 This systematic review found that adding an ACE inhibitor to standard medical therapy reduces the risk of certain serious CV outcomes in patients with stable ischaemic […]
NPC Archive Item: Dronedarone is less effective, but safer than amiodarone in atrial fibrillation
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27 October 2009, An indirect comparison meta-analysis found that dronedarone was significantly less effective than amiodarone in preventing recurrence of AF, but was associated with fewer side effects requiring […]