NPC Archive Item: Rivaroxaban for prevention of venous thromboembolism in patients undergoing total hip or knee replacement

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Eriksson BI, Borris LC, Friedman RJ et al. Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty. N Engl J Med 2008; 358:2765-75 Kakkar AK, Brenner B, Dahl OE […]

NPC Archive Item: QRISK2 – a valid tool for predicting cardiovascular risk?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Hippisley-Cox J, Coupland C, Vinogradova Y, et al. Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2. BMJ 2008;336;1475–82 QRISK2 may provide a more accurate […]

NPC Archive Item: NICE highlights NPC patient decision aid in its lipid guidance

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. NICE Clinical Guideline 67: Cardiovascular risk assessment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease Patients should be given information about their […]

NPC Archive Item: NICE publishes guidance on CV risk assessment and lipid modification

NPC Archive Item: Reducing blood pressure is beneficial in people with hypertension regardless of age

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Blood Pressure Lowering Treatment Trialists’ Collaboration. Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials. BMJ 2008; […]

NPC Archive Item: MHRA issue drug alert for Clexane®

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Medicines and Healthcare products Regulatory Agency (MHRA) have issued advice to healthcare professionals about heparin enoxaparin sodium (Clexane®) pre-filled syringes. The manufacturer of this low molecular weight heparin […]

NPC Archive Item: Treating hypertension in the elderly reduces mortality

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Becket NS, Peters R, Fletcher AE, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med 2008;358. Published 31st March 2008 (10.1056/NEJMoa0801369) […]

NPC Archive Item: No benefit from rosuvastatin in heart failure

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Kjekshus J et al. Rosuvastatin in older patients with systolic heart failure. NEJM 2007; 357: 2248-61 (CORONA study) In this study in people with moderate to severe heart failure, […]

NPC Archive Item: Potential for confusion with new formulation of Coversyl®

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Servier has announced that their branded versions of perindopril erbumine, (Coversyl® and Coversyl Plus®), also known as perindopril tert-butylamine, have been discontinued and replaced with a different salt called […]

NPC Archive Item: ACE-I plus ARB misses the target

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The ONTARGET investigators. Telmisartan, ramipril or both in patients at high risk for vascular events. New Engl J Med 2008; 358; 1547-59 What is the background to this? ACE-inhibitors […]