NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 5th February 2009 An observational study from Tennessee suggests that typical and atypical antipsychotic drugs approximately double the risk of sudden cardiac death. The absolute increase is approximately an […]
Category Archives: CNS and mental health
NPC Archive Item: EMEA recommendations for safer use of methylphenidate-containing medicines
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 4th February 2009 The EMEA’s Committee for Medicinal Products for Human Use (CHMP) has reviewed methylphenidate due to concerns over cardiovascular and cerebrovascular risks. They also considered the risk […]
NPC Archive Item: New evidence to support individualised antipsychotic drug treatment in patients with schizophrenia
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A recent meta-analysis concludes that all antipsychotic drugs differ in their efficacy and adverse effects and they are not a homogeneous group. This supports an individualised approach to treatment, […]
NPC Archive Item: Antipsychotics increase mortality in patients with Alzheimer’s disease
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Extended follow-up of the DART-AD trial found patients with Alzheimer’s disease who continued antipsychotic medication for behavioural or psychiatric problems were twice as likely to die as those switched […]
NPC Archive Item: Tasimelteon for insomnia – early data in healthy people with an artificially disturbed sleep pattern.
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. In healthy people whose sleep pattern had been brought forward by five hours, a single dose of tasimelteon reduced the time to persistent sleep compared to placebo. It is […]
NPC Archive Item: Z-drugs increase the risk of road traffic accidents
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A study in Norway has found that prescription of Z-drugs is associated with around a doubled increased relative risk of road traffic accidents compared to those who don’t take […]
NPC Archive Item: EMEA reinforces safety concerns over using antipsychotics in elderly patients with dementia
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The EMEA has reported that, as with newer (atypical) antipsychotics, conventional (typical) antipsychotics are likely to be associated with increased mortality when used in elderly people with dementia. Action […]
NPC Archive Item: No difference in effectiveness of ‘second-generation’ antidepressants
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A recent systematic review concludes that current evidence does not support the choice of one second-generation antidepressant (e.g. SSRIs, venlafaxine, duloxetine▼, mirtazapine) over another on the basis of efficacy […]
NPC Archive Item: Olanzapine long-acting injection for schizophrenia
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. EMEA Summary of Positive Opinion for olanzapine long-acting injection (Zypadhera ®) In September 2008, the Committee for Medicinal Products for Human Use (CHMP) recommended European licensing approval of olanzapine […]
NPC Archive Item: Concomitant use of an SSRI and NSAID increases the risk of an upper GI bleed six times
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40 The relative risk of […]