NPC Archive Item: Newer antidepressants produce clinically significant benefits over placebo only in the severely depressed

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Kirsch I, et al. Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration. PLoS Med 2008 5(2): 45. doi:10.1371/journal.pmed.0050045 What is the […]

NPC Archive Item: NPC Podcast – 26th February 2008

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Antidepressants – Questions around benefits in non-severe depression / evidence of publication bias [podcast]http://www.npc.nhs.uk/podcast/NPCiPodcast_26thFeb08.mp3[/podcast] Subscribe to the NPC podcast via the iTunes store Subscribe to the NPC podcast via […]

NPC Archive Item: Publication bias in studies of antidepressants?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Turner EH, et al, Selective publication of antidepressant trials and its influence on apparent efficacy. New Engl J Med 2008;358:252-260 What is the background to this? It is important […]

NPC Archive Item: Aripiprazole versus conventional (typical) antipsychotics for schizophrenia

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Bhattacharjee J, El-Sayeh HGG. Aripiprazole versus typicals for schizophrenia. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD006617. DOI: 10.1002/14651858.CD006617.pub2 What is the background to this? – […]

NPC Archive Item: Varenicline▼ compared with nicotine replacement therapy for smoking cessation

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Stapleton JA, et al. Varenicline in the routine treatment of tobacco dependence: a pre-post comparison with nicotine replacement therapy and an evaluation in those with mental illness. Addiction 2008;103:146-54. […]

NPC Archive Item: Cholinesterase inhibitors don’t help in mild cognitive impairment

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Raschetti R, et al. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Medicine 2007; 4(11): e338. doi:10.1371/journal.pmed.0040338 What is the background to this? Dementia […]

NPC Archive Item: Does agomelatine prevent relapse in patients with major depression?

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Which study was this? A conference presentation of Goodwin G, Rouillon F and Emsley R. Long term efficacy of agomelatine, a novel antidepressant, in the prevention of relapse in […]

NPC Archive Item: 4th Drug Safety Update from MHRA/CHM

NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Drug Safety Update is an NHS Evidence accredited provider The MHRA and CHM have published the latest issue of Drug Safety Update (4th November 2007). This contains information […]