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Category Archives: Musculoskeletal pain
Osteoarthritis: evidence review of paracetamol raises further doubts about its effectiveness (and safety) (Apr-15)
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NPC Archive Item: New evidence for naproxen/esomeprazole▼ combination in knee osteoarthritis.
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 25 November 2011 Two 12-week phase III studies found that a fixed-dose combination of naproxen and esomeprazole (Vimovo▼) had comparable upper gastrointestinal (GI) tolerability to celecoxib in people with […]
NPC Archive Item: Even short-term NSAID use can increase cardiovascular risk in patients with prior MI
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 16 June 2011 A Danish cohort study identified an increased risk of death or recurrent myocardial infarction (MI) with non-steroidal anti-inflammatory drugs (NSAIDs) in patients with prior MI. The […]
NPC Archive Item: NSAIDs and cardiovascular risks – more evidence, but this shouldn’t be new news
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 1st February 2011 The conclusions of a network meta-analysis of randomised trials broadly confirm previous research showing an increased risk of cardiovascular (CV) events with many NSAIDs. Naproxen was […]
NPC Archive Item: Scotland says no to glucosamine sulphate product
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 13 December 2010 The Scottish Medicines Consortium (SMC) has recently concluded that the Glusartel®▼ brand of glucosamine sulphate cannot be recommended for use in NHS Scotland for the relief […]
NPC Archive Item: Glucosamine and chondroitin in osteoarthritis: still no good evidence of clinical effectiveness
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 21 October 2010 A network meta-analysis has concluded that glucosamine and chondroitin, given either separately or together, do not affect pain intensity in osteoarthritis (OA) to a clinically meaningful extent […]
NPC Archive Item: CV risk of diclofenac similar to rofecoxib
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 6 July 2010 A large cohort study found that individual NSAIDs have different levels of CV risk. In particular, this study found that diclofenac and rofecoxib were associated with a […]
NPC Archive Item: NICE guidance for low-back pain: acupuncture is an option, but should this be real or simulated?
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 1st July 2009 NICE has issued a clinical guideline on the early management of persistent or recurrent low back pain. The guideline includes recommendations for assessment and imaging, provision […]
NPC Archive Item: June Drug Safety Update from MHRA/CHM
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Drug Safety Update is an NHS Evidence accredited provider 11th June 2009 The MHRA and CHM have published the June edition of Drug Safety Update. This issue gives […]