NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 6th March 2009 A recent observational study has found that people with heart failure who took NSAIDs, particularly at higher doses, were at substantially greater risk of death or […]
Category Archives: Musculoskeletal pain
NPC Archive Item: Rofecoxib is associated with an early increase in cardiovascular events, which persists for a year after stopping treatment
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Baron J, Sandler RS, Bresalier RS, et al. Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. The Lancet. Early online publication 14th October 2008. DOI:10.1016/S0140-6736(08)61490–7 In the […]
NPC Archive Item: Concomitant use of an SSRI and NSAID increases the risk of an upper GI bleed six times
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Loke YK, Trivedi AN, Singh S. Meta-analysis: gastrointestinal bleeding due to interaction between selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 2008;27:31–40 The relative risk of […]
NPC Archive Item: EMEA issues new warning for etoricoxib▼, epoetins and ergot-derived dopamine agonists
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Following reviews of the risks and benefits of several drugs, the European Medicines Agency (EMEA) has recommended that: warnings and contraindications should be strengthened for etoricoxib▼ for the treatment […]
NPC Archive Item: Gastroprotection – no protective advantage for coxibs over traditional NSAIDs among elderly patients on a PPI
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Abraham NS, Hartman C, Castillo D, et al. Effectiveness of national provider prescription of PPI gastroprotection among elderly NSAID users. Am J Gastroenterol 2008;103:323-32 Limited observational data question using […]
NPC Archive Item: NPC Podcast – 25th March 2008
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. NICE osteoarthritis guidance, and PPIs plus coxibs or non-selective NSAIDs [podcast]http://www.npc.nhs.uk/podcast/NPCiPodcast_25thMar08.mp3[/podcast] Subscribe to the NPC podcast via the iTunes store Subscribe to the NPC podcast via RSS feed
NPC Archive Item: NICE publishes clinical guidance on management of osteoarthritis
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. NICE has published its guidance on management of osteoarthritis. ‘Osteoarthritis: the care and management of osteoarthritis in adults’ (NICE CG 59) offers best practice advice on the care of […]
NPC Archive Item: Glucosamine in hip osteoarthritis — still no evidence for its effectiveness
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. Rozendaal RM, et al. Effect of glucosamine sulfate on hip osteoarthritis. A randomized trial. Ann Intern Med 2008; 148: 268–77 What is the background to this? Glucosamine is commonly […]
NPC Archive Item: NPC Podcast – 30th November 2007
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A discussion about the safety of NSAIDs – based on the content of MeReC Extra 30 [podcast]http://www.npc.nhs.uk/podcast/NPCiPodcast_30thNov07.mp3[/podcast] Subscribe to the NPC podcast via the iTunes store Subscribe to the […]