NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 9 December 2009, A phase III randomised controlled trial demonstrated that darusentan reduced systolic/diastolic blood pressure by about 10/5mmHg compared with placebo in patients with treatment-resistant hypertension, but was […]
Category Archives: New medicines
NPC Archive Item: Issues with biosimilars
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 19th November 2009 An article published in the British Medical Journal has noted the high cost of newer biological drugs and offers suggestions for potential ways of making such […]
NPC Archive Item: Roflumilast in COPD
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 18 November 2009, Two one-year RCTs (AURA and HERMES) showed that roflumilast modestly improved lung function in patients with severe COPD who were symptomatic and not using an inhaled […]
NPC Archive Item: Dronedarone is less effective, but safer than amiodarone in atrial fibrillation
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27 October 2009, An indirect comparison meta-analysis found that dronedarone was significantly less effective than amiodarone in preventing recurrence of AF, but was associated with fewer side effects requiring […]
NPC Archive Item: Ticagrelor — another antiplatelet for ACS
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 2 December 2009 Ticagrelor plus aspirin was significantly more effective than clopidogrel plus aspirin in preventing vascular events in patients with acute coronary syndrome in the PLATO trial (NNT=53). […]
NPC Archive Item: Everolimus▼ for advanced renal cell cancer after VEGF-inhibitors have failed
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 2nd October 2009, The phase III RECORD-1 study compared oral everolimus to placebo in 410 patients with metastatic renal cell carcinoma whose disease had progressed despite treatment. The trial […]
NPC Archive Item: Denosumab for postmenopausal osteoporosis
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 15 September 2009 In the FREEDOM study, subcutaneous denosumab was compared with placebo given at 6 monthly intervals over 36 months to almost 8,000 women with postmenopausal osteoporosis. While […]
NPC Archive Item: Gefitinib▼ for locally advanced or metastatic non-small-cell lung cancer
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 24th August 2009, Gefitinib▼ is licensed for use in patients with locally advanced or metastatic non-small-cell lung cancer with activating mutations of the epidermal growth factor receptor tyrosine kinase. […]
NPC Archive Item: Latest data on saxagliptin
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27th July 2009, A phase III, 24 week randomised controlled trial has assessed the efficacy and short-term safety of saxagliptin 2.5, 5 and 10mg versus placebo as add-on therapy […]
NPC Archive Item: Scottish Medicines Consortium reviews fluticasone furoate▼ nasal spray for allergic rhinitis
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27th April 2009 The Scottish Medicines Consortium (SMC) has accepted fluticasone furoate▼ (Avamys®) for use within NHS Scotland for the treatment of the symptoms of allergic rhinitis in adults, adolescents […]