NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 24 June 2010 The FDA has recently rejected a New Drug Application for roflumilast (Daxas®), which was in licensing to reduce exacerbations associated with chronic obstructive pulmonary disease (COPD). Further […]
Category Archives: Respiratory
NPC Archive Item: Antibiotic strategy for preventing complications of sore throat in young people
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. A recent article highlights that Fusobacterium necrophorum is the cause of around 10% of acute pharyngitis cases in adolescents and young adults. One of the supparative complications of this […]
NPC Archive Item: Phase out of chlorofluorocarbon (CFC)-containing pharmaceutical metered dose inhalers
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 7 May 2010 Introduction: Pharmaceutical metered dose inhalers (pMDIs) traditionally used chlorofluorocarbons (CFCs) as the propellant but, under the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer1, […]
NPC Archive Item: Cardiovascular safety of anticholinergics in COPD
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 25 March 2010 A US cohort study in patients with COPD found an increased risk of CV events associated with the use of ipratropium within the past six months. […]
NPC Archive Item: Drug Safety Update from MHRA/CHM (February 2010)
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. The Drug Safety Update is an NHS Evidence accredited provider 19 February 2010 The MHRA and CHM have published the February edition of Drug Safety Update This edition includes […]
NPC Archive Item: Cochrane review does not support ICS plus LABA in steroid naïve patients with persistent asthma
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 12 January 2010 A Cochrane review found that current evidence does not support the use of combination therapy with ICS plus LABA as first choice preventer therapy in adults […]
NPC Archive Item: Observational data in swine influenza pandemic indicate benefit of early antivirals; new Cochrane review finds oseltamivir▼’s ability to prevent complications of seasonal influenza in otherwise healthy adults not proven.
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 22 December 2009 Action Health professionals’ responses to the swine influenza pandemic should not be affected by the controversy regarding oseltamivir▼’s ability to prevent complications of seasonal influenza in […]
NPC Archive Item: Roflumilast in COPD
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 18 November 2009, Two one-year RCTs (AURA and HERMES) showed that roflumilast modestly improved lung function in patients with severe COPD who were symptomatic and not using an inhaled […]
NPC Archive Item: Triple versus single therapy in COPD
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 4 November 2009 A short-term randomised controlled trial claims benefits for the addition of inhaled budesonide/formoterol to tiotropium (i.e. triple vs. single therapy) in patients with COPD. However, limitations […]
NPC Archive Item: Wash your hands (and more): physical barriers help stop viral infections spreading
NOTE – This is an archive post from the NPC and has not been updated since first publication. Therefore, some hyperlinks may no longer be working. 27 October 2009 This updated Cochrane review found that, although the evidence is of limited quality, hygiene and physical barriers can be effective in reducing or preventing the spread […]